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Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
Published on: August 30, 2017
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The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice
Ruyan Wu1,2, Jianfeng Liu1, Robert Seaman1
1Department of Pharmacology and Toxicology, University At Buffalo, The State University of New York, 955 Main Street, Buffalo, NY, 14214, USA.
Psychopharmacology
|July 22, 2021
Summary
Activation of trace amine-associated receptor 1 (TAAR1) enhances memory retrieval. The TAAR1 agonist RO5263397 improved both short-term and long-term recognition memory in mice, highlighting TAAR1
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor involved in neurotransmission.
- TAAR1 agonists exhibit pro-cognitive effects, but their impact on memory performance is not well understood.
Purpose of the Study:
- To investigate the effects of the selective TAAR1 partial agonist RO5263397 on recognition memory.
- To assess RO5263397's impact on short-term and long-term memory using the novel object recognition (NOR) test in mice.
Main Methods:
- Utilized the novel object recognition (NOR) test in mice to evaluate memory.
- Administered the selective TAAR1 partial agonist RO5263397.
- Compared memory performance in wild-type (WT) and TAAR1-knockout (TAAR1-KO) mice.
Main Results:
- RO5263397 significantly enhanced short-term memory (STM) retrieval in both male and female mice.
- The memory-enhancing effects of RO5263397 were dependent on the presence of TAAR1, as observed in WT but not TAAR1-KO mice.
- RO5263397 also promoted the retrieval of long-term NOR memory (24 hours post-training).
Conclusions:
- TAAR1 activation promotes novel object recognition memory retrieval.
- These findings support the pro-cognitive potential of TAAR1 agonists.
