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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Changes in platelet count and coagulation parameters in children with obstructive sleep apnea

Tian Shen1, Jing Wang1, Linke Li1

  • 1Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Sleep & Breathing = Schlaf & Atmung
|July 22, 2021
PubMed

Insights

Children with obstructive sleep apnea (OSA) show elevated platelet counts, which correlate with OSA severity. This study found no evidence of coagulation disorders in children with OSA.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Hematology

Background:

  • Obstructive sleep apnea (OSA) is a common condition in children.
  • The relationship between OSA and coagulation status requires further investigation.
  • Understanding these links can inform potential therapeutic strategies.

Purpose of the Study:

  • To investigate the correlation between obstructive sleep apnea (OSA) and coagulation status in children.
  • To explore the underlying mechanisms linking OSA and coagulation.
  • To compare coagulation parameters in children with and without OSA.

Main Methods:

  • 345 children diagnosed with OSA (age 2-14 years) were categorized into four groups based on their apnea-hypopnea index (AHI).
  • Platelet (PLT) counts and various coagulation parameters were compared across these groups.
  • Linear regression analysis was employed to examine correlations between polysomnography metrics (AHI, ODI, oxygen saturation) and coagulation parameters.

Main Results:

  • Children with OSA exhibited significantly higher PLT counts compared to non-OSA controls (P < 0.001).
  • The AHI and oxygen desaturation index (ODI) showed a positive correlation with PLT count.
  • Lower minimum and mean oxygen saturation levels were negatively correlated with PLT count, while other coagulation tests (PT, INR, aPTT, TT, fibrinogen) showed no significant differences.

Conclusions:

  • Children with OSA demonstrate elevated platelet counts, which are positively associated with OSA severity.
  • No significant coagulation disorders were identified in children with OSA.
  • The findings suggest that increased platelet activation or count may be a mechanism linked to OSA in pediatric populations.
Abstract

Keywords:
Apnea–hypopnea indexCoagulation disorderCoagulation parametersHypoxiaObstructive sleep apneaPlatelet

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