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Updated: Oct 27, 2025

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Altered behavioral and electrophysiological responses to social fairness in manic and euthymic patients with bipolar
Vin Ryu1, Ra Yeon Ha2, Hyun-Sang Cho3,4
1Department of Psychiatry, National Center for Mental Health, Ministry of Health and Welfare, Seoul, South Korea.
Background:
Individuals with bipolar disorder show mood instability, including heightened anger and impulsivity. The Ultimatum Game (UG) is a tool used to evaluate emotional and social decision-making strategies. We investigated behavioral and electrophysiological responses to subjectively fair or unfair offers in the UG in patients with bipolar I disorder.
Methods:
Twenty-four manic patients, 20 euthymic patients, and 30 healthy controls participated in this study. We analyzed their behaviors and collected electroencephalography data with which to analyze feedback-related negativity (FRN) as they played in the UG as responders.
Results:
Manic patients exhibited significantly higher rejection rates for unfair offers than euthymic patients and healthy controls. Healthy individuals exhibited a greater (i.e., more negative) FRN amplitude in response to unfair offers than to fair offers, whereas euthymic patients exhibited a greater FRN amplitude in response to fair offers compared with unfair offers. Manic patients exhibited no difference in FRN amplitudes between fair and unfair offers.
Conclusions:
The current data suggest that different behavioral responses and FRN amplitude patterns can be associated with characteristic manifestations of mood instability in manic bipolar patients. In addition, electrophysiological alterations in response to unfair offers may be a trait abnormality independent of mood state.
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