Myogenic tremor - a novel tremor entity.

Area of Science:

• Neurology
• Muscle Physiology
• Genetics

Background:

• Tremor is a common neurological symptom with diverse causes, often originating in the central or peripheral nervous system.
• Myogenic tremor, identified in 2019, is a distinct tremor type believed to arise from the muscle itself.
• Understanding tremor origins is crucial for accurate diagnosis and treatment.

Purpose of the Study:

• To review the clinical characteristics of myogenic tremor.
• To discuss the presumed pathogenesis of myogenic tremor based on published cases.
• To differentiate myogenic tremor from other tremor types.

Main Methods:

• Literature review of published patient cases of myogenic tremor.
• Analysis of clinical properties and presumed pathogenesis.
• Comparison with centrally mediated tremors and other myopathies.

Main Results:

• Myogenic tremor is a high-frequency, postural, and kinetic tremor with infantile onset.
• It is associated with myopathies affecting contractile elements, particularly myosin.
• The tremor generator is hypothesized to be in the sarcomere, with CNS reflex loop involvement.

Conclusions:

• Myogenic tremor is linked to sarcomere-associated mutations.
• Distinguishing true myogenic tremor from central nervous system myopathies is essential.
• Myogenic tremor can be a valuable diagnostic marker for specific myopathies.