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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
144
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Related Experiment Video

Updated: Oct 27, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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Dengue and the heart.

Diego Araiza-Garaygordobil1, Carlos Eduardo García-Martínez2, Lucrecia María Burgos3

  • 1Coronary Care Unit, National Institute of Cardiology of Mexico, Mexico.

Cardiovascular Journal of Africa
|July 22, 2021
PubMed
Summary

Dengue fever, a tropical disease, can cause serious heart problems. Early detection and treatment of cardiovascular complications are vital to prevent severe outcomes like heart failure.

Keywords:
cardiovascular involvementdenguemyocarditisneglected tropical diseases

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Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Cardiology

Background:

  • Dengue is a significant tropical arthropod-borne viral disease.
  • It poses a substantial global health and economic burden.
  • Cardiovascular (CV) manifestations are serious complications of dengue.

Purpose of the Study:

  • To systematically review and identify cardiovascular manifestations associated with dengue.
  • To highlight the importance of recognizing and managing these complications.

Main Methods:

  • A systematic review of relevant studies was performed.
  • Literature search conducted in MEDLINE and PubMed databases.
  • Included 30 studies detailing dengue's CV impact.

Main Results:

  • Identified CV complications include: rhythm abnormalities, hypotension, myocarditis, pericarditis, and myocardial dysfunction.
  • These complications contribute to mortality and disability.
  • Patients are at risk for cardiogenic shock and heart failure.

Conclusions:

  • Cardiovascular complications are a critical aspect of dengue patient care.
  • Prompt diagnosis and management are essential for improving patient outcomes.
  • Addressing CV issues in dengue can reduce morbidity and mortality.