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The production of 99mTc-labeled conjugated antibodies using a cyclam-based bifunctional chelating agent
J Franz1, W A Volkert, E K Barefield
1Department of Radiology, University of Missouri-Columbia.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1987
Abstract:
A bifunctional chelating agent (BFCA) based on a macrocyclic amine, cyclam, was used to form specifically 99mTc labeled rabbit-anti-HSA-antibodies. This study demonstrates the feasibility of forming a highly stable cyclam-based 99mTc-BFCA with its subsequent conjugation to antibodies.