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Ongoing global and regional adaptive evolution of SARS-CoV-2

Nash D Rochman1, Yuri I Wolf2, Guilhem Faure3

  • 1National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894; nash.rochman@nih.gov zhang@broadinstitute.org Koonin@ncbi.nlm.nih.gov.

Proceedings of the National Academy of Sciences of the United States of America
|July 22, 2021
PubMed
Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution is mainly driven by purifying selection, with key mutations in spike and nucleocapsid proteins indicating positive selection and global diversification shifts during the COVID-19 pandemic.

Keywords:
SARS-Cov-2ancestral reconstructionepistasisglobalizationphylogeny

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