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Related Experiment Videos

Developing a core outcome set for periodontal trials.

Thomas J Lamont1, Jan E Clarkson1, David N J Ricketts1

  • 1Dundee Dental School & Hospital, University of Dundee, Dundee, United Kingdom.

Plos One
|July 22, 2021
PubMed
Summary
This summary is machine-generated.

A new core outcome set (COS) for periodontal disease trials standardizes measurements like probing depths and tooth loss. This reduces research waste and uncertainty for patients and dental professionals.

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Area of Science:

  • Periodontology
  • Dental Public Health
  • Clinical Trial Methodology

Background:

  • Lack of consensus on outcome measurement in periodontal disease interventions leads to research inefficiency.
  • Inconsistent outcome reporting hinders comparison and combination of study findings.
  • This uncertainty impacts patients and healthcare professionals involved in periodontal care.

Purpose of the Study:

  • To develop a standardized core outcome set (COS) for periodontal disease prevention and management trials.
  • To ensure outcomes measured are relevant to key stakeholders, including patients and dental professionals.
  • To improve the comparability and utility of research in periodontology.

Main Methods:

  • A mixed-methods approach was employed, integrating a literature review, an online Delphi study, and a face-to-face consensus meeting.
  • Stakeholders, including patients and various dental professionals, participated in prioritizing outcomes.
  • The process involved multiple rounds of feedback and consensus-building to finalize the COS.

Main Results:

  • A literature review identified 37 potential outcomes for periodontal disease research.
  • Iterative Delphi rounds involving 71 patients and dental professionals refined the outcome list.
  • The final core outcome set includes: Probing depths, Quality of life, Quantified levels of gingivitis, Quantified levels of plaque, and Tooth loss.

Conclusions:

  • Implementing this core outcome set will enhance the relevance of future periodontal disease trial results.
  • Standardized outcomes reduce research waste and uncertainty, providing clearer evidence for patient and professional decision-making.
  • The COS aims to strengthen the quality and certainty of evidence regarding intervention effectiveness in periodontology.