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Prevalence of hyperventilation in patients with asthma
Duco D Deenstra1,2, Hanneke A C van Helvoort1, Remco S Djamin3
1Department of Respiratory Diseases, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Summary
Hyperventilation is common in stable asthma patients, affecting 40% overall. Chronic hyperventilation is linked to younger females with better lung function. The Nijmegen Questionnaire is not effective for screening asthma-related hyperventilation.
Area of Science:
- Respiratory Medicine
- Pulmonology
- Clinical Physiology
Background:
- Asthma management often overlooks dysfunctional breathing patterns like hyperventilation.
- Prevalence data for hyperventilation in stable asthma is limited, hindering effective diagnosis.
- The utility of the Nijmegen Questionnaire (NQ) for identifying hyperventilation in asthma remains unverified.
Purpose of the Study:
- To determine the prevalence of hyperventilation in a large cohort of stable asthma patients.
- To compare clinical characteristics between asthma patients with and without hyperventilation.
- To assess the concurrent validity of the NQ in detecting hypocapnia in asthma.
Main Methods:
- A real-world, observational, multicenter study design.
- Capillary blood gas analysis in 1006 adult patients with stable asthma.
- Administration of the Nijmegen Questionnaire to a subset of participants.
Main Results:
- Hyperventilation was identified in 17% (acute) and 23% (chronic) of patients.
- Chronic hyperventilation was associated with female gender, younger age, and superior spirometry outcomes.
- The Nijmegen Questionnaire showed no correlation with PCO2 levels.
Conclusions:
- Hyperventilation is a prevalent comorbidity in stable asthma.
- Chronic hyperventilation in asthma exhibits distinct demographic and physiological characteristics.
- The Nijmegen Questionnaire is unsuitable for screening hyperventilation in stable asthma patients.
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