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Validation of the Mini-Addenbrooke's Cognitive Examination in Mild Cognitive Impairment in Arabic Speakers

Tarik Qassem1,2,3, Mohamed S Khater4, Tamer Emara5

  • 1Maudsley Health, Al-Amal Psychiatric Hospital, Dubai, United Arab Emirates.

Dementia and Geriatric Cognitive Disorders
|July 22, 2021
PubMed
Abstract

Insights

The Arabic mini-Addenbrooke's Cognitive Examination (m-ACE) is a validated tool for detecting mild cognitive impairment (MCI) in Egyptian Arabic speakers. It demonstrated good sensitivity and specificity, offering a crucial screening option for MCI diagnosis.

Area of Science:

  • Neurology
  • Cognitive Science
  • Psychometrics

Background:

  • Mild cognitive impairment (MCI) is a critical stage for early dementia intervention.
  • A lack of validated Arabic screening tools hinders MCI detection.
  • The mini-Addenbrooke's Cognitive Examination (m-ACE) is a rapid cognitive assessment tool.

Purpose of the Study:

  • To validate the Arabic version of the m-ACE in Egyptian patients with MCI.
  • To establish cut-off scores for MCI detection using the Arabic m-ACE.

Main Methods:

  • Administered the Arabic m-ACE to 24 MCI patients and 52 controls in Egypt.
  • Analyzed total and sub-scores for significant differences.
  • Correlated m-ACE performance with MMSE and ACE-III.
  • Utilized ROC curve analysis to determine optimal cut-off scores.

Main Results:

  • Statistically significant differences in total m-ACE scores between MCI patients and controls (p < 0.0001).
  • Significant differences observed in fluency, visuospatial, and memory recall sub-scores.
  • Optimal cut-off score for MCI was 21/30, with 87.5% sensitivity, 84.6% specificity, and 85.5% accuracy.
  • Strong correlations found between m-ACE, MMSE, and ACE-III.

Conclusions:

  • The Arabic m-ACE is a validated and objective screening tool for MCI in Egyptian Arabic speakers.
  • The tool exhibits performance comparable to other translated m-ACE versions.
  • This validation addresses the need for accessible MCI screening tools in the Arabic-speaking population.
Keywords:
ArabicEgyptMild cognitive impairmentMini-Addenbrooke’s Cognitive ExaminationValidation

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