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Published on: May 10, 2021
Impact of skin invasion on long-term survival outcomes in gingivobuccal complex carcinoma
Smriti Panda1, Rajeev Kumar1, Ashwin Chandran C1
1Department of Otolaryngology, All India Institute of Medical Sciences, New Delhi, India.
Introduction:
Gingivo-buccal complex cancers (GBCC) have an aggressive clinical course in the presence of skin and bone involvement.
Objective:
This study intends to analyze the clinico-pathological factors affecting local control and survival outcomes in GBCC.
Methods:
This is a retrospective study conducted on 125 GBCC cases from January 2011 to April 2016.
Result:
Univariate analysis revealed lymphovascular invasion (LVI) and skin involvement as predictors of poor overall survival (OS) and disease- free survival (DFS). Multivariate analysis showed skin involvement and LVI to be independent prognostic factors towards poor OS. Corresponding results in case of DFS showed skin involvement to be the single most important prognostic factor. With a median follow up of 24 months, the median survival of patients with skin involvement, skin and mandible invasion and isolated mandible invasion, respectively, were 18 months, 12 months and 22 months.
Conclusion:
GBCC with skin involvement portends poor outcome in terms of survival. In the presence of skin invasion, treatment entails liberal soft tissue and bone margin followed by adjuvant treatment.
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