Aortic Dilatation in Patients With Bicuspid Aortic Valve

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Jing Wang1,2,3, Wenhui Deng1,2,3, Qing Lv1,2,3

  • 1Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Physiology
|July 23, 2021
PubMed

Insights

Bicuspid aortic valve (BAV) disease, the most common heart defect, can lead to aortic dilatation and serious complications. Current monitoring relies on limited aortic diameter measurements, highlighting a need for better understanding of BAV aortopathy.

Area of Science:

  • Cardiology
  • Genetics
  • Vascular Biology

Background:

  • Bicuspid aortic valve (BAV) is the most prevalent congenital heart anomaly.
  • BAV is linked to aortic dilatation, increasing risks of dissection and rupture, posing a significant health burden.
  • Current management relies on aortic diameter, which has limited predictive value.

Purpose of the Study:

  • To review current knowledge on BAV aortopathy.
  • To explore clinical definitions, epidemiology, natural course, and pathophysiology.
  • To discuss hemodynamic and clinical aspects of BAV aortopathy.

Main Methods:

  • Comprehensive literature review.
  • Analysis of existing data on BAV aortopathy.
  • Synthesis of current understanding of BAV disease progression.

Main Results:

  • BAV aortopathy is a complex condition with limited understanding of its progression.
  • Aortic diameter is the primary but insufficient metric for surgical intervention.
  • There is a need for improved diagnostic and prognostic tools.

Conclusions:

  • BAV aortopathy requires further research to improve patient outcomes.
  • Enhanced understanding of pathophysiology and hemodynamics is crucial.
  • Development of novel monitoring and intervention strategies is warranted.

Keywords:
aneurysmaortic dilationaortopathybicuspid aortic valvenature history

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