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Related Experiment Video

Updated: Oct 27, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Acute pulmonary function decline and radiographic abnormalities: chronic cause?

Kathleen M Capaccione¹, Clement V Tran¹, Jay S Leb¹

¹Dept of Radiology, Columbia University Irving Medical Center, New York, NY, USA.

Breathe (Sheffield, England)

|July 23, 2021

Summary

This summary is machine-generated.

Nitrofurantoin can cause drug-induced pneumonitis, leading to interstitial lung disease. This can occur even with long-term use, presenting significant respiratory symptoms and requiring chest CT evaluation.

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Area of Science:

Pulmonology
Pharmacology
Radiology

Background:

Nitrofurantoin is a common antibiotic used for urinary tract infections.
Drug-induced lung injury is a known adverse effect of various medications.
Chronic medication use can sometimes lead to delayed adverse reactions.

Purpose of the Study:

To highlight nitrofurantoin as a potential cause of drug-induced pneumonitis.
To describe the clinical presentation of nitrofurantoin-induced lung disease.
To emphasize the utility of chest CT in diagnosing this condition.

Main Methods:

Review of clinical cases and relevant literature.
Analysis of patient data including medication history and respiratory symptoms.
Correlation of clinical findings with chest CT imaging.

Main Results:

Nitrofurantoin can induce pneumonitis, a form of interstitial lung disease.
Clinically significant respiratory symptoms may arise from this condition.
Chest CT is crucial for identifying characteristic lung changes.

Conclusions:

Nitrofurantoin should be considered in patients presenting with interstitial lung disease, even with chronic use.
Early recognition and diagnosis are vital for managing nitrofurantoin-induced pneumonitis.
Pulmonary toxicity can manifest despite a history of well-tolerated chronic nitrofurantoin therapy.