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It's not all about inhaled treatment: challenges with oral therapy in paediatric respiratory medicine

Anneka Sareen1, Manisha Ramphul2, Jayesh Mahendra Bhatt2

  • 1Pharmacy Dept, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK.

Breathe (Sheffield, England)
|July 23, 2021
PubMed

Insights

Managing cystic fibrosis in children involves significant treatment burdens from multiple oral medications. New therapies present challenges, but strategies exist to ease care for young patients with chronic respiratory conditions.

Area of Science:

  • Pediatric Respiratory Medicine
  • Pharmacology
  • Chronic Disease Management

Background:

  • Advances in pediatric respiratory care improve survival in chronic diseases like cystic fibrosis.
  • Increased survival leads to a higher treatment burden, including numerous inhaled and oral medications.
  • Paediatric oral formulations require consideration of palatability and administration to enhance adherence.

Purpose of the Study:

  • To describe challenges children with chronic respiratory conditions face with oral medications.
  • To discuss potential oral drug interactions and polypharmacy issues in paediatric respiratory medicine.
  • To highlight strategies for reducing the treatment burden in children on oral medication.

Main Methods:

  • Literature review focusing on paediatric respiratory conditions, oral medications, and treatment burden.
  • Analysis of challenges related to polypharmacy and drug interactions in cystic fibrosis management.
  • Exploration of strategies for improving adherence and reducing care burden for children and families.

Main Results:

  • Children with chronic respiratory conditions experience significant difficulties with oral medication regimens.
  • New cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies introduce complex interactions and adverse reactions.
  • Strategies for reducing treatment burden and improving adherence are crucial for patient well-being.

Conclusions:

  • Optimizing oral formulations and managing polypharmacy are essential in paediatric respiratory care.
  • Addressing treatment burden is key to improving quality of life for children with chronic respiratory diseases.
  • Further research into effective strategies for managing complex medication regimens in paediatric patients is warranted.

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