Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pelvic Lymph Node Dissection in Prostate Cancer: Update from a Randomized Clinical Trial of Limited Versus Extended Dissection.

European urology·2024

Same author

Successful completion of large, low-cost randomized cancer trials at an academic cancer center.

Clinical trials (London, England)·2024

Same author

Testosterone Therapy in Men After Radical Prostatectomy for Low-Intermediate Organ-Confined Prostate Cancer.

The Journal of urology·2024

Same author

Re: Early Prostate Cancer Deaths Among Men with Higher vs Lower Genetic Risk.

European urology·2024

Same author

Transperineal vs Transrectal Prostate Biopsy-The PREVENT Randomized Clinical Trial.

JAMA oncology·2024

Same author

Clinical utility of an artificial intelligence radiomics-based tool for risk stratification of pulmonary nodules.

JNCI cancer spectrum·2024

Search research articles

Related Experiment Video

Updated: Oct 27, 2025

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

Active surveillance for prostate cancer.

Daniela K Shill¹, Monique J Roobol², Behfar Ehdaie³

¹Hunter College, New York, NY, USA.

Translational Andrology and Urology

|July 23, 2021

Summary

Active surveillance (AS) for localized prostate cancer is safe, with low metastasis and death risks. This approach avoids treatment side-effects for many men, improving quality of life.

Keywords:

Active surveillance (AS)cohort expectant management program prostate cancer watchful waiting

More Related Videos

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Published on: June 10, 2025

Related Experiment Videos

Last Updated: Oct 27, 2025

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Published on: June 10, 2025

Area of Science:

Oncology
Urology
Public Health

Background:

Localized prostate cancer management often involves active treatment, leading to potential side-effects.
Active surveillance (AS) offers an alternative by monitoring patients and initiating treatment only upon disease progression.

Purpose of the Study:

To review long-running active surveillance cohorts to determine the safety and efficacy of AS for prostate cancer.
To assess metastasis and mortality risks associated with AS in diverse patient groups.

Main Methods:

A narrative review of 14 articles from 13 active surveillance cohorts was conducted.
Cohorts varied in inclusion criteria, including low- and intermediate-risk prostate cancer patients.

Main Results:

Prostate cancer metastasis risk ranged from 0.1-1.0% at 10 years; mortality risk ranged from 0-1.9% at 10 years.
The majority of studies reported risks below 0.5% for both metastasis and death at 10 years.
Half of men in most cohorts remained untreated for 5-10 years.

Conclusions:

Active surveillance is a safe management strategy for men with low-grade prostate cancer and selected intermediate-risk cases.
Broader implementation of AS can improve quality of life by avoiding unnecessary active treatments.
Further research is needed to define optimal AS criteria for intermediate-risk prostate cancer patients.