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Temporal Learning Among Prefrontal and Striatal Ensembles.

Eric Emmons¹, Gabriela Tunes-Chiuffa², Jeeyu Choi³

¹Department of Psychiatry, Yale University, New Haven, CT 06515, USA.

Cerebral Cortex Communications

|July 23, 2021

Summary

The medial frontal cortex (MFC) and dorsomedial striatum (DMS) show distinct roles in temporal learning. Neuronal activity in the MFC decreases, while the DMS improves temporal decoding when adapting to new time intervals.

Keywords:

corticostriatal interval timing learning prefrontal cortex striatum

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Area of Science:

Neuroscience
Behavioral Neuroscience
Cognitive Neuroscience

Background:

Behavioral flexibility relies on the prefrontal cortex and striatum.
The specific roles of these structures in adapting to new situations remain unclear.

Purpose of the Study:

Investigate neuronal ensembles in the medial frontal cortex (MFC) and dorsomedial striatum (DMS).
Examine their distinct roles in learning a new temporal interval, a form of behavioral flexibility.

Main Methods:

Studied rodent corticostriatal neuronal activity during training.
Compared neuronal activity between a 12-s fixed interval (FI12) and a 3-s fixed interval (FI3).
Analyzed time-related ramping activity and temporal decoding by neuronal ensembles.

Main Results:

Time-related ramping activity decreased in the MFC but not the DMS when learning a shorter interval.
Temporal decoding by DMS ensembles improved on FI3 trials.
More DMS neurons than MFC neurons showed differential interval-related activity early in learning.

Conclusions:

The MFC and DMS play distinct roles in temporal learning.
Provides insights into the function of corticostriatal circuits in behavioral flexibility.