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Collaborative clinical laboratory evaluation of an individual MIC strip system
H D Isenberg1, R F D'Amato, G A McKinley
1Long Island Jewish Medical Center, New Hyde Park, New York 11042.
Journal of Clinical Microbiology
|December 1, 1987
Summary
Individualized MIC strips (MICRO-MIC) demonstrated high agreement with standard microdilution methods. This finding supports MICRO-MIC as a reliable tool for antimicrobial susceptibility testing.
Area of Science:
- Clinical microbiology
- Antimicrobial resistance
- Diagnostic testing
Background:
- Accurate antimicrobial susceptibility testing (AST) is crucial for guiding effective treatment.
- Standard microdilution broth methods are widely used but can be labor-intensive.
- Novel AST methods are needed to improve efficiency and accessibility.
Purpose of the Study:
- To evaluate the performance of individualized MIC strips (MICRO-MIC) compared to a standard method.
- To determine the agreement of MICRO-MIC results across multiple antimicrobial agents.
Main Methods:
- Antimicrobial susceptibility testing was performed using both MICRO-MIC and standard microdilution broth methods.
- Ten different antimicrobial agents were tested.
- Concordance rates between the two methods were calculated.
Main Results:
- MICRO-MIC showed excellent agreement with the standard microdilution broth method.
- Agreement levels were 96% or greater for all 10 antimicrobial agents tested.
- This indicates high reliability and reproducibility of the MICRO-MIC system.
Conclusions:
- Individualized MIC strips (MICRO-MIC) provide accurate and reliable antimicrobial susceptibility results.
- MICRO-MIC is a viable alternative to standard microdilution methods.
- The findings support the clinical utility of MICRO-MIC for guiding antimicrobial therapy.
