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Related Experiment Video

Updated: Oct 27, 2025

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

Targeting Nanoparticles to Bioengineered Human Vascular Networks.

Kathleen Cullion^1,2, Laura C Petishnok^1,2, Hyunji Koo^1,2

¹Laboratory for Biomaterials and Drug Delivery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.

|July 23, 2021

Summary

Targeted nanoparticles show promise for treating vascular anomalies. Phototargeting significantly increased nanoparticle and drug accumulation in engineered human vascular networks, improving treatment efficacy and reducing toxicity.

Keywords:

bioengineered human vascular network micelle phototargeted nanoparticle tissue engineering vascular anomalies

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Last Updated: Oct 27, 2025

Bioengineering Human Microvascular Networks in Immunodeficient Mice

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Published on: July 11, 2011

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

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Micropatterning and Assembly of 3D Microvessels

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Published on: September 9, 2016

Area of Science:

Biomedical Engineering
Nanotechnology
Pharmacology

Background:

Vascular anomalies present treatment challenges due to limited drug efficacy and significant toxicity.
Nanoparticle (NP) drug delivery systems offer potential for targeted accumulation in impaired vasculature, enhancing efficacy and reducing off-target toxicity.

Purpose of the Study:

To investigate the use of phototargeted NPs for enhanced drug delivery to bioengineered human vascular networks (hVNs).
To model vascular anomalies and assess NP accumulation and drug delivery efficiency.

Main Methods:

Intravenous injection of phototargeted NPs into hVNs.
Quantification of NP accumulation within hVNs and other organs.
Measurement of drug (doxorubicin) accumulation in hVNs compared to free drug administration.

Main Results:

Phototargeting significantly enhanced NP accumulation within hVNs by 17-fold compared to non-targeted NPs.
Phototargeted NPs showed a 10-fold greater accumulation in hVNs than in any other organ.
Phototargeting led to a 6-fold increase in doxorubicin accumulation within hVNs compared to free drug administration.

Conclusions:

Phototargeted nanoparticle delivery systems can markedly improve drug accumulation in vascular anomalies.
This approach holds significant potential for enhancing the efficacy and reducing the toxicity of pharmacotherapy for vascular anomalies.