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Related Experiment Video

Updated: Oct 27, 2025

Measuring Replicative Life Span in the Budding Yeast
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Pterocarpus marsupium extract extends replicative lifespan in budding yeast.

Mitchell B Lee1, Michael G Kiflezghi1, Mitsuhiro Tsuchiya1

  • 1Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.

Geroscience
|July 23, 2021
PubMed
Summary

Researchers screened natural products for longevity effects in yeast. Pterocarpus marsupium extract showed the most significant lifespan extension, suggesting its potential for future studies in higher organisms.

Keywords:
Lifespan-extending interventionsNatural productsSaccharomyces cerevisiaemTOR inhibitors

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Area of Science:

  • Gerontology and molecular biology
  • Yeast as a model organism for aging research

Background:

  • Understanding biological aging mechanisms is key to developing interventions for extended health and longevity.
  • The budding yeast Saccharomyces cerevisiae is a valuable model for studying cellular aging and testing longevity interventions.

Purpose of the Study:

  • To screen natural products and mixtures for their effects on yeast growth rate, mTOR-mediated growth inhibition, and replicative lifespan.
  • To identify potential natural product interventions for promoting longevity.

Main Methods:

  • Screening of natural products and mixtures in Saccharomyces cerevisiae.
  • Assessment of effects on growth rate, mTOR pathway activity, and replicative lifespan.

Main Results:

  • No mTOR inhibitory activity was detected among the tested natural products.
  • Green tea extract and berberine demonstrated lifespan shortening effects.
  • Extracts of Pterocarpus marsupium showed the most significant lifespan extension.

Conclusions:

  • The yeast model system is effective for discovering longevity interventions.
  • Pterocarpus marsupium extract is a promising candidate for longevity interventions and warrants further investigation in higher eukaryotes.