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Updated: Oct 27, 2025

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Organs-on-chip: The way forward.

Massimo Mastrangeli1, Janny van den Eijnden-van Raaij2

  • 1Delft University of Technology, Delft, the Netherlands.

Stem Cell Reports
|July 23, 2021
PubMed
Summary
This summary is machine-generated.

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Organ-on-chip (OoC) technology is advancing rapidly. Standardization and independent testing are crucial for realizing its full potential in drug development and personalized medicine.

Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Drug Discovery

Background:

  • Organ-on-chip (OoC) technology is experiencing significant growth, driven by advancements in stem cell biology and global research initiatives.
  • The increasing availability of stem cells and dedicated international programs are fueling the expansion of OoC applications.

Discussion:

  • Standardization, qualification, and independent testing are essential for the cohesive advancement of OoC technology.
  • These efforts are necessary to overcome current limitations and ensure reliable performance of OoC devices.
  • Addressing these aspects will facilitate the integration of OoC systems into mainstream research and clinical practices.

Key Insights:

  • The potential of OoC technology in drug development, disease modeling, and personalized medicine is substantial.
Keywords:
disease modelingdrug developmentmicrophysiological systemsorgan-on-chippersonalized medicinequalificationroadmapstandardizationstem cell

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  • Realizing this potential requires a concerted effort towards establishing robust quality control and validation frameworks.
  • A clear roadmap is vital for guiding the future development and implementation of OoC.

    • Outlook:

    • The development of a comprehensive OoC roadmap will accelerate progress in the field.
    • This roadmap will guide future research, development, and regulatory acceptance of OoC technologies.
    • Successful implementation of the roadmap will unlock new possibilities in pharmaceutical research and healthcare.