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Related Experiment Video

Updated: Oct 27, 2025

New Thrombectomy Technique for Total Portal Vein Thrombosis in Liver Transplantation

New Thrombectomy Technique for Total Portal Vein Thrombosis in Liver Transplantation

Published on: June 27, 2025

The first virtual patient-specific thrombectomy procedure.

Giulia Luraghi¹, Sara Bridio¹, Jose Felix Rodriguez Matas¹

¹Laboratory of Biological Structure Mechanics (LaBS), Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Milan, Italy.

Journal of Biomechanics

|July 23, 2021

Summary

This summary is machine-generated.

Computational modeling accurately replicated endovascular mechanical thrombectomy for acute ischemic stroke, confirming two attempts were needed for clot removal due to stent retriever positioning. This simulation aids in optimizing procedures and improving stent designs.

Keywords:

Acute ischemic stroke Finite element analysis INSIST In silico Stent-retriever

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Published on: May 6, 2020

Area of Science:

Biomedical Engineering
Neurology
Medical Imaging

Background:

Endovascular mechanical thrombectomy has improved acute ischemic stroke treatment for large vessel occlusions.
Further advancements in thrombectomy procedures and stent design are actively being pursued.
Computational studies offer a powerful tool for simulating and understanding these complex interventions.

Purpose of the Study:

To virtually replicate a patient-specific endovascular mechanical thrombectomy procedure for intracranial large vessel occlusion.
To analyze the factors influencing clot removal success and identify potential areas for procedural and device improvement.
To validate the use of computational modeling in optimizing thrombectomy operations.

Main Methods:

Creation of a patient-specific cerebral vasculature model from computed tomography (CT) images.
Histologic analysis to determine the composition of the intracranial clot.
Virtual simulation of the entire endovascular mechanical thrombectomy procedure, including stent retriever deployment.
Analysis of stent retriever-clot interaction, clot deformation, and fragmentation.

Main Results:

The computational simulation accurately reproduced the clinical observation that two attempts were necessary for clot removal.
The necessity for multiple attempts was attributed to the specific positioning of the stent retriever relative to the clot.
No significant clot fragmentation was observed, with deformations primarily occurring in a compressive state.
The simulation demonstrated limited propagation of clot cracks due to compressive forces.

Conclusions:

Accurate computational replication of endovascular mechanical thrombectomy is feasible and valuable.
Simulation insights can guide operative planning and optimize future stent retriever designs for improved clot removal efficacy.
This approach provides a foundation for enhancing patient outcomes in acute ischemic stroke treatment.