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Callosal Diffusion-Restriction in Patients with Intracranial Hemorrhage
Tracey H Fan1, G Abbas Kharal2, Jessica Biedny3
1Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.
Summary
Diffusion-restricting lesions in the corpus callosum (CC) are rare in patients with intracranial hemorrhage (ICH), particularly those with intraventricular hemorrhage (IVH). Further research is needed to understand the cause and significance of these findings.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Intracranial hemorrhage (ICH) can lead to various secondary complications.
- Diffusion-weighted imaging (DWI) is crucial for detecting acute ischemic changes.
- The corpus callosum (CC) is a critical white matter structure in the brain.
Purpose of the Study:
- To determine the incidence of diffusion-restricting lesions in the corpus callosum (CC) in patients with intracranial hemorrhage (ICH).
- To describe the clinical characteristics and imaging findings of these lesions.
- To investigate potential associations with intraventricular hemorrhage (IVH).
Main Methods:
- Retrospective analysis of adult patients with ICH treated with nicardipine infusion.
- Exclusion of patients without brain MRI or those who underwent DSA prior to MRI.
- Evaluation of MRI scans for DWI lesions in the CC, ICH, and intraventricular hemorrhage (IVH) volumes.
Main Results:
- Six out of 162 patients (4%) presented with CC DWI lesions.
- All patients with CC lesions also had intraventricular hemorrhage (IVH).
- No clear infectious or metabolic causes were identified; DSA was mostly normal.
Conclusions:
- Diffusion-restricting lesions in the CC are an uncommon finding in ICH patients, especially with concurrent IVH.
- The etiology and clinical significance of these CC lesions require further investigation.
- These findings highlight a potential imaging association in severe ICH cases.
