Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New mutation causing hereditary hepatitis in the laboratory rat.

M C Yoshida1, R Masuda, M Sasaki

  • 1Chromosome Research Unit, Faculty of Science, Hokkaido University, Sapporo, Japan.

The Journal of Heredity
|November 1, 1987
PubMed
Summary

A novel hereditary hepatitis in LEC rats causes severe jaundice and liver damage. This discovery offers a new animal model for studying hepatitis and liver cancer development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Expandable metallic stent therapy for SVC syndrome--effects on local venous pressure, vascular diameter, symptoms, and these correlations].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same author

[Biological effects of static gradient magnetic field on cultured mammalian cells and combined effects with 60Co gamma-rays].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same author

Bleomycin but not its derivatives inhibits the in vivo shedding of a rat tumor-associated antigen.

Anti-cancer drugs·1992
Same author

Isolation of cDNA for bovine stomach 155 kDa protein exhibiting myosin light chain kinase activity.

Journal of biochemistry·1992
Same author

Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH.

Journal of bacteriology·1992
Same author

Cooperative modulation of voltage-dependent sodium channels by brevetoxin and classical neurotoxins in cultured bovine adrenal medullary cells.

The Journal of pharmacology and experimental therapeutics·1992

Area of Science:

  • Hepatology
  • Genetics
  • Animal Models

Background:

  • Hereditary hepatitis is a significant health concern.
  • The LEC rat strain presents a unique opportunity for research.

Purpose of the Study:

  • To characterize a new mutant causing hereditary hepatitis in LEC rats.
  • To investigate the genetic basis of this condition.
  • To evaluate the potential of LEC rats as a model for hepatitis and liver cancer.

Main Methods:

  • Observation of clinical signs in affected rats.
  • Histological examination of liver tissues.
  • Genetic analysis to determine inheritance patterns.

Main Results:

  • Hepatitis manifests in adult rats (3-4 months) with jaundice, bleeding, oliguria, and weight loss.

Related Experiment Videos

  • Affected rats exhibit high lethality and liver necrosis without inflammation.
  • Genetic studies suggest a single autosomal recessive gene is responsible.
  • Liver cancer develops in some long-term survivors and asymptomatic rats.

    • Conclusions:

    • LEC rats harbor a mutation causing hereditary hepatitis and jaundice.
    • This mutation is likely due to a single autosomal recessive gene.
    • LEC rats serve as a valuable animal model for studying hepatitis and liver cancer pathogenesis, prevention, and treatment.