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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

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Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions.

Lynn Bitar¹, Ulrike Schumann², Renate König³

¹Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network, University Medical Center of The Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

|July 24, 2021

Summary

The neural-immune axis impacts cancer and autoimmune diseases. Targeting immune checkpoints in glioblastoma may offer therapeutic benefits but carries risks for autoimmune conditions like multiple sclerosis.

Keywords:

autoimmune disease clinical trials glioma immune checkpoints immunotherapy

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Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

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Published on: September 1, 2018

Area of Science:

Neuroimmunology
Cancer Biology
Immunotherapy

Background:

The immune system closely interacts with the nervous system, influencing health and disease.
The neural-immune interface is critical for regulating cancer progression and autoimmune disorders.
Glioblastoma multiforme (GBM) poses therapeutic challenges due to potent immunosuppression within its tumor microenvironment.

Purpose of the Study:

To review promising immune-modulatory targets for glioblastoma treatment.
To explore the dual role of these targets in both cancer therapy and autoimmune disease development.
To highlight the complex interplay between the nervous and immune systems in disease pathogenesis.

Main Methods:

Literature review of preclinical and clinical studies on immune checkpoint molecules.
Analysis of immunosuppressive mechanisms in the glioblastoma tumor microenvironment.
Examination of immune system homeostasis and its failure in cancer and autoimmune diseases.

Main Results:

Immune checkpoint molecules are key mediators of immunosuppression in GBM.
Targeting these molecules is a promising immunotherapy strategy for glioblastoma.
Dysregulation of immune checkpoints can potentially trigger autoimmune diseases, such as multiple sclerosis.

Conclusions:

Understanding the neural-immune interface is crucial for developing effective cancer immunotherapies.
Immune-modulatory targets in glioblastoma research require careful consideration due to potential autoimmune side effects.
Further research is needed to balance therapeutic efficacy with the risk of inducing autoimmune conditions.