Related Experiment Video
Updated: Oct 27, 2025
06:51
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
18.2K
Clinical and Imaging Features of Non-Small Cell Lung Cancer with G12C KRAS Mutation
Markus Y Wu1, Eric W Zhang1, Matthew R Strickland2
1Department of Radiology, Division of Thoracic Imaging and Intervention, Massachusetts General Hospital, Boston, MA 02114, USA.
Cancers
|July 24, 2021
Summary
KRAS G12C mutations in non-small cell lung cancer (NSCLC) show distinct imaging features and metastasis patterns. These findings differentiate G12C NSCLC from other KRAS mutations and genetic alterations.
Area of Science:
- Oncology
- Radiology
- Genetics
Background:
- KRAS G12C mutations are key drivers in non-small cell lung cancer (NSCLC).
- These mutations predict sensitivity to targeted G12C inhibitors.
- Understanding NSCLC subtypes based on genetic alterations is crucial for treatment.
Purpose of the Study:
- To compare imaging features and metastasis patterns of KRAS G12C NSCLC.
- To differentiate G12C NSCLC from non-G12C KRAS NSCLC.
- To contrast G12C NSCLC with NSCLC driven by EGFR mutations and fusion events (RET, ALK, ROS1).
Main Methods:
- Retrospective analysis of 215 NSCLC patients (2015-2019).
- Categorization into G12C (83 patients), non-G12C KRAS (132 patients), fusion rearrangements, and EGFR mutations.
- Assessment of primary tumor imaging and metastatic distribution at diagnosis.
Main Results:
- G12C NSCLC showed higher rates of cavitation and lung metastasis compared to non-G12C KRAS.
- G12C NSCLC had less pleural metastasis and lymphangitic carcinomatosis but more brain metastasis than fusion-driven NSCLC.
- G12C NSCLC exhibited lower lung metastasis and higher distant nodal metastasis rates versus EGFR-mutated NSCLC.
Conclusions:
- KRAS G12C NSCLC presents unique primary tumor imaging characteristics.
- Distinct metastatic patterns are observed in G12C NSCLC compared to other NSCLC subtypes.
- Imaging features can aid in differentiating NSCLC driven by KRAS G12C from other oncogenic drivers.
