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Updated: Oct 27, 2025
08:32
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018
9.8K
Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma
Clara Bertuzzi1, Elena Sabattini1, Claudio Agostinelli1,2
1Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Cancers
|July 24, 2021
Summary
Classical Hodgkin's lymphoma (cHL) involves unique Reed-Sternberg cells interacting with the tumor microenvironment. This microenvironment influences cHL development and offers potential therapeutic targets.
Area of Science:
- Oncology
- Immunology
- Pathogenesis
Background:
- Classical Hodgkin's lymphoma (cHL) comprises 10% of lymphoma diagnoses.
- cHL is characterized by Hodgkin cells (HCs) and Reed-Sternberg cells (HRSCs) within a reactive microenvironment (ME).
- HRSCs modulate the ME by releasing cytokines, influencing immune cell function and promoting tumor survival.
Purpose of the Study:
- To review the role of the ME in cHL pathogenesis and prognosis.
- To explore the ME as a potential therapeutic target in cHL.
Main Methods:
- Literature review focusing on the interaction between HRSCs and the ME.
- Analysis of cytokine production and immune cell modulation within the cHL microenvironment.
Main Results:
- The ME plays a critical role in cHL pathogenesis by supporting tumor cell survival and immune evasion.
- HRSCs actively shape the ME, creating a niche that favors tumor progression.
- Immune cell populations are functionally altered within the ME to provide prosurvival signals to cancer cells.
Conclusions:
- The reactive microenvironment is integral to the development and progression of cHL.
- Targeting the ME presents a promising therapeutic strategy for cHL treatment.
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