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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
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Related Experiment Video

Updated: Oct 27, 2025

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
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Transition between Random and Periodic Electron Currents on a DNA Chain.

Elham Faraji1,2,3,4, Roberto Franzosi5, Stefano Mancini3,4

  • 1Aix-Marseille Univ, Université de Toulon, CNRS, CPT, 13288 Marseille, France.

International Journal of Molecular Sciences
|July 24, 2021
PubMed
Summary
This summary is machine-generated.

Electron motion in DNA chains shows sequence-dependent charge transfer. This finding suggests novel electrodynamic interactions for DNA, potentially influencing transcription factor binding and electromagnetic field responses.

Keywords:
DNA chainsDavydov modelHolstein-Fröhlich modelelectron currenttime dependent variational principle

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Area of Science:

  • Computational physics
  • Molecular biophysics
  • DNA dynamics

Background:

  • The Davydov and Holstein-Fröhlich models are foundational for studying excitation energy transport in molecular chains.
  • Understanding electron dynamics in DNA is crucial for comprehending its biological functions and potential applications.

Purpose of the Study:

  • To investigate electron motion along a DNA fragment modeled as a chain of heavy particles.
  • To explore how excitation site and external energy influence electron current characteristics.

Main Methods:

  • Utilizing a model Hamiltonian in second quantization.
  • Applying the Time Dependent Variational Principle to derive system dynamics.
  • Analyzing electron current spectra under external energy input.

Main Results:

  • Electron current exhibits either a broad or sharply peaked frequency spectrum.
  • The observed phenomenology is dependent on the DNA sequence and excitation site.
  • This suggests sequence-dependent charge transfer within the DNA model.

Conclusions:

  • DNA's electrodynamic interactions are potentially rich and sequence-dependent.
  • Electron excitation can lead to varied charge transfer behaviors.
  • These findings may explain DNA interactions with transcription factors and external fields.