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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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High-Density Lipoproteins and Cardiovascular Disease: The Good, the Bad, and the Future
Josep Julve1,2,3, Joan Carles Escolà-Gil1,2,3
1Institut d'Investigacions Biomèdiques IIB Sant Pau, 08041 Barcelona, Spain.
International Journal of Molecular Sciences
|July 24, 2021
Insights
Low high-density lipoprotein cholesterol (HDL-C) levels are linked to higher risks of atherosclerotic cardiovascular disease (CVD). This highlights HDL-C
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
Background:
- Low plasma high-density lipoprotein cholesterol (HDL-C) is a recognized risk factor for atherosclerotic cardiovascular disease (CVD).
- Understanding the mechanisms linking low HDL-C to CVD is crucial for developing effective prevention and treatment strategies.
Discussion:
- The association between low HDL-C and increased CVD risk is supported by epidemiological, clinical, and experimental evidence.
- Further research is needed to elucidate the complex pathways involved in HDL-C's atheroprotective effects and the consequences of its deficiency.
Key Insights:
- Low HDL-C levels are consistently associated with elevated atherosclerotic cardiovascular disease risk.
- This association underscores the importance of HDL-C in maintaining cardiovascular health.
Outlook:
- Future research should focus on therapeutic strategies to increase HDL-C levels or enhance its function to mitigate CVD risk.
- Investigating novel biomarkers and therapeutic targets related to HDL-C metabolism may offer new avenues for CVD prevention.
Abstract:
Epidemiological, clinical, and experimental studies have shown that low levels of plasma high-density lipoprotein cholesterol (HDL-C) are associated with increased atherosclerotic cardiovascular disease (CVD) [...].
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