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Updated: Oct 27, 2025

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
Published on: February 3, 2017
Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure
Abou Bakr M Salama1,2,3, Ahmad Gebreil1, Tamer M A Mohamed1,4,5,6,7
1Department of Medicine, Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, 580 S. Preston St., Rm 122, Louisville, KY 40202, USA.
Abstract:
Unlike some lower vertebrates which can completely regenerate their heart, the human heart is a terminally differentiated organ. Cardiomyocytes lost during cardiac injury and heart failure cannot be replaced due to their limited proliferative capacity. Therefore, cardiac injury generally leads to progressive failure. Here, we summarize the latest progress in research on methods to induce cardiomyocyte cell cycle entry and heart repair through the alteration of cardiomyocyte plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions.
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