Organocatalytic Enantiospecific Total Synthesis of Butenolides
Rudrakshula Madhavachary1, Rosy Mallik1, Dhevalapally B Ramachary1
1Catalysis Laboratory, School of Chemistry, University of Hyderabad, Central University (P.O.), Gachibowli, Hyderabad 500 046, India.
Abstract:
Biologically important, chiral natural products of butenolides, (-)-blastmycinolactol, (+)-blastmycinone, (-)-NFX-2, (+)-antimycinone, lipid metabolites, (+)-ancepsenolide, (+)-homoancepsenolide, mosquito larvicidal butenolide and their analogues were synthesized in very good yields in a sequential one-pot manner by using an organocatalytic reductive coupling and palladium-mediated reductive deoxygenation or organocatalytic reductive coupling and silica-mediated reductive deamination as the key steps.
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