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Polysaccharide- and β-Cyclodextrin-Based Chiral Selectors for Enantiomer Resolution: Recent Developments and
Cuong Viet Bui1,2, Thomas Rosenau1,3, Hubert Hettegger1
1Department of Chemistry, Institute of Chemistry of Renewable Resources, University of Natural Resources and Life Sciences, Konrad-Lorenz-Straße 24, Tulln, A-3430 Vienna, Austria.
Polysaccharides and β-cyclodextrins are key chiral selectors (CSs) for chiral stationary phases (CSPs) in chromatography. Recent advancements focus on CSP preparation, recognition mechanisms, and enantiomeric separation (ES) methods.
Area of Science:
- Analytical Chemistry
- Separation Science
- Chiral Chemistry
Background:
- Polysaccharides and β-cyclodextrins are established chiral selectors (CSs).
- These CSs are utilized in chiral stationary phases (CSPs) for enantiomeric separation (ES).
- Traditional CSP preparation involves physical coating or chemical immobilization onto silica gel.
Purpose of the Study:
- To review recent developments in CSs, CSP preparation, and chiral recognition mechanisms.
- To summarize advancements in enantiomeric separation (ES) methods using polysaccharide and β-cyclodextrin-based CSPs.
- To focus on the period of 2019-2020 in this rapidly evolving field.
Main Methods:
- Literature review of recent developments (2019-2020).
- Analysis of new chiral selectors and CSP preparation techniques.
- Elucidation of chiral recognition mechanisms in enantiomeric separation.
Main Results:
- Introduction of novel chiral selectors.
- Exploitation of progressive methods for CSP preparation.
- Enhanced understanding of chiral recognition mechanisms and functional performance of CSPs.
- Gained insights into enantiomeric separation (ES) capabilities.
Conclusions:
- Polysaccharides and β-cyclodextrins remain vital for chiral chromatography.
- Continued innovation in CSPs and separation methodologies is evident.
- Improved understanding of chiral recognition enhances enantiomeric separation efficiency.
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