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Estimating an EQ-5D-3L Value Set for Romania Using Time Trade-Off.

Marian Sorin Paveliu^1,2, Elena Olariu³, Raluca Caplescu⁴

¹Romanian Academic Society, 020071 Bucharest, Romania.

International Journal of Environmental Research and Public Health

|July 24, 2021

Summary

A new country-specific value set for the EQ-5D-3L questionnaire was developed in Romania. This provides crucial health-related quality of life data to support health technology assessment and reimbursement decisions.

Keywords:

EQ-5D cost-utility analysis health-related quality of life quality-adjusted life years time trade-off utilities

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Area of Science:

Health Economics
Quality of Life Research
Health Technology Assessment

Background:

Health technology assessment (HTA) and reimbursement decisions require robust health-related quality of life (HRQoL) data.
Country-specific value sets are essential for accurate HRQoL assessments.
Romania previously lacked a dedicated value set for the EQ-5D-3L questionnaire.

Purpose of the Study:

To develop a country-specific value set for the EQ-5D-3L questionnaire in Romania.
To generate HRQoL data to inform HTA and reimbursement processes.
To establish a foundation for locally relevant HTA in Romania.

Main Methods:

The time trade-off (cTTO) method was employed for health state valuation.
Computer-assisted personal interviewing followed the EuroQoL Visual Analogue Scale (EQ-VT) protocol.
Econometric modeling, specifically an interval regression model, was used to derive values for all 243 EQ-5D-3L health states.

Main Results:

A national representative sample of 1556 non-institutionalized adults provided the data.
The developed EQ-5D-3L value set ranged from 0.969 to 0.399.
Mobility was identified as the most important dimension, followed by pain/discomfort, self-care, anxiety/depression, and usual activities.

Conclusions:

The developed value set will support reimbursement decisions in Romania.
This resource facilitates regional cross-country comparisons of health technologies.
The study advances Romania's capacity for data-driven health technology assessment.