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Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
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The Link between SARS-CoV-2 Infection, Inflammation and Hypercoagulability-Impact of Hemorheologic Alterations on

Johanna Sandor-Keri1, Istvan Benedek2, Stefania Polexa1

  • 1Clinic of Cardiology, University of Medicine, Pharmacy, Science, and Technology, George Emil Palade of Targu Mures, 540139 Targu Mures, Romania.

Journal of Clinical Medicine
|July 24, 2021
PubMed

Insights

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection increases cardiovascular risks. Inflammation and hypercoagulability are key factors, with neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as potential prognostic markers.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Hematology

Background:

  • Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is linked to increased cardiovascular complications and mortality.
  • Inflammation and hypercoagulability are implicated in both severe COVID-19 and cardiovascular events like acute myocardial infarction.

Purpose of the Study:

  • To review recent findings on the relationship between SARS-CoV-2 infection, inflammation, and blood coagulability.
  • To explore the role of these factors in major cardiovascular events.

Main Methods:

  • Literature review of studies investigating SARS-CoV-2, cardiovascular diseases, inflammation, and coagulability.
  • Analysis of prognostic markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).

Main Results:

  • SARS-CoV-2 infection elevates cardiovascular risks, particularly in patients with pre-existing heart conditions.
  • Inflammation and hypercoagulability are critical pathophysiological links between COVID-19 and cardiovascular events.
  • NLR and PLR show potential as independent prognostic markers for COVID-19 severity.

Conclusions:

  • Understanding the interplay between SARS-CoV-2, inflammation, and coagulability is crucial for managing cardiovascular risks.
  • NLR and PLR may serve as valuable tools for predicting disease severity and outcomes in COVID-19 patients.

Keywords:
NLRPLRSARS-CoV-2hemorheologyhypercoagulabilityinflammationmyocardial infarction

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