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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Preeclampsia and Cardiovascular Risk for Offspring

Wiktor Wojczakowski1, Żaneta Kimber-Trojnar1, Filip Dziwisz2

  • 1Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.

Journal of Clinical Medicine
|July 24, 2021
PubMed

Insights

Children exposed to preeclampsia in utero face increased risks of cardiovascular disease later in life. This involves fetal and postnatal programming, but clear causal links remain complex to establish.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatrics
  • Cardiovascular Medicine

Background:

  • Preeclampsia is a pregnancy complication associated with maternal hypertension and placental issues.
  • Offspring of mothers with preeclampsia exhibit higher risks for long-term cardiovascular diseases (CVD).
  • Mechanisms involve fetal and postnatal programming, influenced by genetic, molecular, and environmental factors.

Purpose of the Study:

  • To discuss the association between preeclampsia during pregnancy and the potential for cardiovascular disease in offspring.
  • To explore the complex interplay of factors contributing to this risk.

Main Methods:

  • Literature review and synthesis of existing evidence.
  • Discussion of proposed mechanisms including fetal programming and environmental influences.

Main Results:

  • Growing evidence links in utero preeclampsia exposure to later-life cardiovascular sequelae in children.
  • Increased risks observed include hypertension, stroke, and diabetes in offspring.
  • The multifactorial nature of CVD development complicates the establishment of direct dependency mechanisms.

Conclusions:

  • Pregnancy complicated by preeclampsia poses a significant long-term cardiovascular risk to offspring.
  • Understanding fetal and postnatal programming is crucial for risk assessment.
  • Further research is needed to fully elucidate the direct causal pathways between preeclampsia and offspring CVD.

Keywords:
cardiovascular riskfetal programminggestational hypertensionoffspringpreeclampsia

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