Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gd<sub>2</sub>O<sub>3</sub>-Al<sub>2</sub>O<sub>3</sub>-C Ternary Aerogel/Mullite Fiber Composites for High-Efficiency Synergistic Thermal Insulation and Neutron Shielding.

ACS applied materials & interfaces·2026
Same author

Intermetallic nanoassemblies potentiate systemic STING activation.

Science (New York, N.Y.)·2026
Same author

ATP-P2X7R-NLRP3 Axis as a Unifying Mechanism of ATP-Induced Cell Death in Degenerative Bone and Cardiovascular Diseases.

Journal of inflammation research·2026
Same author

Conductive and Self-Adhesive Polyelectrolyte Hydrogel Sensor for Flexible Wearable Devices and Reusable Physiological Electrode.

Macromolecular rapid communications·2026
Same author

Close and Enhance the Cancer-Immunity Cycle by Engineered Dual-Targeted Nano-Adaptors.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Novel stable "sandwich" cyclodextrin inclusion of a lipophilic S-nitrosothiol for controlled delivery of nitric oxide.

Materials & design·2026

Related Experiment Video

Updated: Oct 27, 2025

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
08:12

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

13.0K

Low-Diffusion Fricke Gel Dosimeters with Core-Shell Structure Based on Spatial Confinement.

Wei Zhang1, Kaikai Wang1, Yufeng Zeng1

  • 1College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211100, China.

Materials (Basel, Switzerland)
|July 24, 2021
PubMed
Summary

Researchers developed low-diffusion Fricke gel dosimeters using a core-shell structure to improve radiotherapy dose verification. The novel dosimeters effectively prevent ferric ion diffusion, maintaining accuracy over time.

Keywords:
Fricke gel dosimeterPDMScoatingion diffusionspatial confinement

More Related Videos

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

10.5K
In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
06:34

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

6.5K

Related Experiment Videos

Last Updated: Oct 27, 2025

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
08:12

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

13.0K
Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

10.5K
In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
06:34

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

6.5K

Area of Science:

  • Medical Physics
  • Radiotherapy Dosimetry
  • Materials Science

Background:

  • Ferric ion diffusion in Fricke gel dosimeters limits accurate 3D dose verification in radiotherapy.
  • Spatial confinement strategies are needed to overcome diffusion limitations.

Purpose of the Study:

  • To construct low-diffusion Fricke gel dosimeters with a core-shell structure.
  • To evaluate the effectiveness of spatial confinement in preventing ferric ion diffusion.
  • To assess the dosimetric properties of the developed core-shell dosimeters.

Main Methods:

  • Microdroplet ultrarapid freezing and coating technology were used to create core-shell pellets.
  • Polydimethylsiloxane (PDMS) hydrophobic coating was applied to the pellets.
  • Ion diffusion was measured using ultraviolet-visible spectrophotometry and magnetic resonance imaging after partial beam irradiation.
  • Monte Carlo simulations were performed to analyze dosimetric properties.

Main Results:

  • The core-shell Fricke gel dosimeters exhibited no ferric ion diffusion between pellets even after 96 hours.
  • Diffusion length at the irradiation boundary was confined to the pellet diameter (2-3 mm).
  • The PDMS shell demonstrated minimal impact on the dosimeter's overall performance.

Conclusions:

  • Core-shell Fricke gel dosimeters effectively prevent ferric ion diffusion, enhancing their suitability for radiotherapy applications.
  • The developed dosimeters offer improved accuracy and reliability for 3D dose verification.
  • PDMS coating is a viable method for creating low-diffusion dosimeters without compromising accuracy.