Related Experiment Video
Updated: Oct 27, 2025
12:13
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
7.0K
Multi-gene mutation metastatic castrate-resistant prostate cancer
Joshua Christy1, Emad Kandah2, Kavitha Kesari3
1Internal Medicine, McLaren Regional Medical Center, Flint, Michigan, USA joshua.christy@mclaren.org.
BMJ Case Reports
|July 24, 2021
Summary
This study reports the first case of metastatic castrate-resistant prostate cancer (mCRPC) with five DNA mutations identified via gene panel sequencing. These mutations suggest potential sensitivity to targeted therapies like olaparib and pembrolizumab.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Metastatic castrate-resistant prostate cancer (mCRPC) management benefits from targeted therapies.
- Gene panel sequencing aids in identifying actionable mutations for personalized treatment.
Observation:
- A 75-year-old male patient presented with hematuria and elevated prostate-specific antigen, indicative of advanced prostate cancer.
- CT imaging revealed prostate gland enlargement and metastatic lymph nodes.
- Biopsy confirmed adenocarcinoma of the prostate.
Findings:
- Gene panel sequencing identified five distinct DNA mutations in the mCRPC patient.
- These mutations suggest potential therapeutic sensitivity to olaparib and pembrolizumab.
- This represents the first documented case of mCRPC with five mutations detected by gene panel analysis.
Implications:
- Genomic analysis can guide precise, targeted therapy selection for mCRPC.
- Poly (ADP-ribose) polymerase (PARP) inhibitors may offer survival benefits in mCRPC patients with specific mutations.
- Early integration of gene sequencing could optimize treatment strategies for mCRPC.
More Related Videos
Related Concept Videos
02:21Cancers Originate from Somatic Mutations in a Single Cell
13.3K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
13.3K
01:33Cancer-Critical Genes I: Proto-oncogenes
9.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.4K
02:56Treatment Resistant Cancers
3.5K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K
03:03mTOR Signaling and Cancer Progression
4.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.0K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
8.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.4K