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Related Experiment Videos

Visual evoked blink reflex in optic neuritis.

J P Malin1

  • 1Neurologische Klinik mit klinischer Neurophysiologie, Medizinische Hochshule Hannover, Federal Republic of Germany.

Journal of Neurology
|October 1, 1987
PubMed
Summary
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Optic neuritis patients showed abnormal blink reflexes (BR) in the acute stage. Abnormalities in BR predicted multiple sclerosis development and correlated with MRI findings.

Area of Science:

  • Neuroscience
  • Ophthalmology

Background:

  • Optic neuritis (ON) is an inflammatory condition affecting the optic nerve.
  • The blink reflex (BR) is a neurological response to stimuli, involving facial muscles.

Purpose of the Study:

  • To investigate the optically evoked blink reflex (BR) in patients with acute optic neuritis (ON).
  • To assess the predictive value of BR abnormalities for multiple sclerosis (MS) development.
  • To correlate BR findings with cranial magnetic resonance imaging (MRI) results.

Main Methods:

  • Optically evoked blink reflex (BR) was recorded in 30 acute optic neuritis (ON) patients and 50 healthy controls.
  • Patients were monitored during the acute stage, monthly for the first month, and at 2 and 6 months.
  • Follow-up included monitoring for multiple sclerosis (MS) development and cranial MRI.

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Main Results:

  • In the acute stage, 26/30 ON patients had altered BR amplitudes, while latencies were normal.
  • Six patients (20%) developed MS within 5 years; their BR showed increased latencies and decreased amplitudes.
  • Abnormal BR correlated with abnormal cranial MRI findings; 90% had abnormal pattern-shift visual evoked potentials.

Conclusions:

  • Optically evoked blink reflex (BR) abnormalities are common in acute optic neuritis (ON).
  • BR changes, particularly increased latency and decreased amplitude, may indicate a higher risk of developing multiple sclerosis (MS).
  • BR findings correlate with MRI abnormalities, suggesting its utility in assessing ON and predicting MS.