Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Fine structural changes in idiopathic pulmonary haemosiderosis.

B Corrin¹, M Jagusch, A Dewar

¹Cardiothoracic Institute, London, U.K.

The Journal of Pathology

|November 1, 1987

Summary

Idiopathic pulmonary haemosiderosis primarily damages the alveolar capillaries, particularly the endothelium and basement membrane. This electron microscopy study found more severe changes in children but no evidence of the disease

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A new approach for assessing the radioecological risk associated with the legacy discharge of oil derived natural radioactivity in the UK North Sea.

Marine pollution bulletin·2025

Same author

Does it run in the family? - Improving radiological risk assessment in the coastal environment using taxonomic and phylogenetic perspectives in macroalgae species.

Marine pollution bulletin·2024

Same author

The Duke Activity Status Index compared with cardiopulmonary exercise testing in patients undergoing pre-operative assessment for cancer surgery.

Anaesthesia·2023

Same author

Enhancing radiological monitoring of <sup>137</sup>Cs in coastal environments using taxonomic signals in brown seaweeds.

Journal of environmental radioactivity·2023

Same author

A seafood risk tool for assessing and mitigating chemical and pathogen hazards in the aquaculture supply chain.

Nature food·2023

Same author

An Account of the Wounded on Board His Majesty's Ship Queen Charlotte, in the Battle of Algiers.

Medico-chirurgical journal : or, Quarterly register of medical and surgical science·2017

Area of Science:

Pulmonary Pathology
Electron Microscopy
Pediatric Lung Disease

Background:

Idiopathic pulmonary haemosiderosis (IPH) is a rare lung disease characterized by recurrent pulmonary hemorrhage.
The precise pathological mechanisms and causative factors of IPH remain incompletely understood.

Purpose of the Study:

To investigate the ultrastructural changes in lung biopsies from patients with idiopathic pulmonary haemosiderosis.
To compare pathological findings between pediatric and adult patients with IPH.

Main Methods:

Transmission electron microscopy (TEM) was used to examine lung biopsies.
Six patients (four children, two adults) with diagnosed IPH were included.

Main Results:

Related Experiment Videos

The primary site of damage in IPH is the alveolar capillary endothelium and its basement membrane.

Capillary endothelial swelling, narrowing, and platelet aggregation were common findings.

Haemosiderin deposition was observed in the alveolar epithelium, macrophages, and elastin.

Conclusions:

The alveolar capillary is the major site of injury in idiopathic pulmonary haemosiderosis.
While significant ultrastructural damage is evident, the underlying cause of IPH was not identified in this study.