Perspectives on interstitial photodynamic therapy for malignant tumors
Katarzyna Komolibus1, Carl Fisher1, Johannes Swartling2
1Tyndall National Institute, Ireland.
Journal of Biomedical Optics
|July 24, 2021
Summary
Interstitial photodynamic therapy (IPDT) offers a minimally invasive, effective treatment for solid tumors. Advancements suggest IPDT could become a standard cancer care option with further clinical trials and optimization.
Area of Science:
- Oncology
- Photomedicine
- Cancer Therapeutics
Background:
- Malignant diseases are a leading global cause of death despite advances in cancer treatment.
- Interstitial photodynamic therapy (IPDT) presents a promising alternative for solid tumor management.
Purpose of the Study:
- To review recent advancements in IPDT for solid tumors.
- To propose the integration of IPDT into standard-of-care (SoC) guidelines for specific cancers.
Main Methods:
- Description of current SoC treatments for solid tumors.
- Presentation of IPDT's advantages and applications in selected tumor types.
- Consideration of future research and development opportunities for IPDT.
Main Results:
- Significant improvements in IPDT implementation driven by academic, clinical, and industrial research.
- Demonstrated unique benefits of IPDT in treating solid tumors.
- Potential for IPDT acceptance into SoC guidelines through further clinical trials and optimization.
Conclusions:
- IPDT is a compelling, minimally invasive treatment with mild side effects.
- The adaptability of IPDT allows for optimized and personalized cancer therapy.
