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Tamm-Horsfall protein outside the kidney
1Department of Pathology, University of Birmingham, The Medical School, UK.
The Journal of Pathology
|December 1, 1987
Summary
Tamm-Horsfall protein, primarily found in urine, was detected outside the kidney in abnormal tissues. This protein serves as a marker for extravasated urine in various urinary tract conditions.
Area of Science:
- Urology
- Nephrology
- Immunohistology
Background:
- Tamm-Horsfall protein (THP) is the predominant protein in normal urine.
- Limited research has explored THP distribution beyond the kidney.
- THP's role in pathological conditions outside the kidney is not well understood.
Purpose of the Study:
- To investigate the presence and location of THP in human tissues using immunohistology.
- To determine if THP can serve as a marker for extravasated urine in abnormal conditions.
Main Methods:
- An antiserum specific to Tamm-Horsfall protein was utilized.
- Immunohistological techniques were applied to examine various human tissues.
- Normal and abnormal organs were analyzed for THP deposition.
Main Results:
- THP was exclusively found in the kidney in normal organs.
- Abnormal locations for THP included ulcers exposed to urine, bladder walls post-surgery, and lymph nodes near obstructed kidneys.
- Minimal cellular response was observed around THP deposits.
Conclusions:
- Tamm-Horsfall protein is a reliable immunohistological marker for extravasated urine.
- THP detection is valuable in diagnosing urinary tract fistulas, post-operative urinary complications, and urine reflux into lymphatic systems.