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Related Experiment Video

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A Soft and Absorbable Temporary Epicardial Pacing Wire.

Chen Hang1,2,3, Li Ding1,4, Shiyu Cheng2

  • 1Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|July 24, 2021
PubMed
Summary
This summary is machine-generated.

A new soft and absorbable temporary epicardial pacing wire (saTPW) effectively corrects abnormal heart rates. This innovative cardiac pacing solution minimizes complications and offers a biodegradable alternative for cardiovascular treatments.

Keywords:
bioelectronicsliquid metalspoly(L-lactide-co-ε-caprolactone)temporary epicardial pacing wire

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Engineering
  • Medical Devices

Background:

  • Existing temporary epicardial pacing wires (TPWs) are rigid and non-absorbable, posing risks of severe complications post-cardiac surgery.
  • There is a need for safer, more biocompatible temporary pacing solutions in cardiovascular medicine.

Purpose of the Study:

  • To develop and evaluate a novel soft and absorbable temporary epicardial pacing wire (saTPW).
  • To assess the efficacy of saTPW in correcting abnormal heart rates and its biocompatibility in preclinical models.

Main Methods:

  • Development of saTPW using poly(l-lactide-co-ε-caprolactone) and liquid metal.
  • Evaluation of conductivity, flexibility, cycling stability, and inflammatory response in rat models via subcutaneous implantation.
  • Assessment of bradycardia and ventricular premature beat correction in a rabbit model.

Main Results:

  • The saTPW demonstrated excellent conductivity, flexibility, and cycling stability (>100,000 cycles).
  • Minimal inflammatory response and approximately 13% mass loss over two months of subcutaneous implantation in rats, indicating biodegradability.
  • Effective correction of abnormal heart rates, including bradycardia and ventricular premature beats, in a rabbit model.

Conclusions:

  • The developed saTPW is a promising, safe, and effective alternative to traditional rigid, non-absorbable pacing wires.
  • Its biocompatibility, absorbability, and performance offer a reduced risk of secondary injury and a platform for advanced cardiovascular diagnosis and therapy.