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Updated: Oct 27, 2025

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
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Switching TNFα inhibitors: Patterns and determinants

Rosanne W Meijboom1,2, Helga Gardarsdottir2,3,4, Matthijs L Becker1,5

  • 1Pharmacy Foundation of Haarlem Hospitals, Haarlem, The Netherlands.

Pharmacology Research & Perspectives
|July 24, 2021
PubMed
Summary

Approximately one in six patients switched TNFα-inhibitor (TNFα-i) therapy, primarily to another TNFα-i. Key factors influencing switching included dose escalation and high-dose corticosteroid use in rheumatic diseases and inflammatory bowel disease patients.

Keywords:
biological productsdrug utilizationinflammatory bowel diseasespharmacoepidemiologyrheumatologytumor necrosis factor inhibitors

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