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Association Between Hemoglobin and Major Adverse Cardiac Events: A Secondary Analysis from A Retrospective Cohort
Caiyun Feng1, Yongxiu Ye1, Ting Wang1
1Department of Nursing, People's Hospital of Longhua Shenzhen, Shenzhen, China.
Insights
Lower hemoglobin levels are linked to increased major adverse cardiac events (MACE) in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). This finding suggests hemoglobin is a useful prognostic indicator for cardiac events.
Area of Science:
- Cardiology
- Hematology
Background:
- Stable coronary artery disease (CAD) is a significant health concern.
- Percutaneous coronary intervention (PCI) is a common treatment for CAD.
- Understanding prognostic indicators for adverse events post-PCI is crucial.
Purpose of the Study:
- To investigate the association between hemoglobin levels and major adverse cardiac events (MACE) in patients with stable CAD after PCI.
- To determine if hemoglobin can serve as a prognostic marker for MACE.
Main Methods:
- Retrospective cohort study of 204 patients with stable CAD.
- Patients categorized into four hemoglobin level groups.
- Lasso regression for variable selection and odds ratios (OR) with 95% confidence intervals (CI) for analysis.
Main Results:
- A negative association was observed between hemoglobin levels and MACE incidence post-PCI.
- This negative correlation persisted after adjusting for confounding variables.
- Curve fitting confirmed a non-linear, negative relationship between hemoglobin and MACE.
Conclusions:
- Hemoglobin level is a significant prognostic indicator for MACE in CAD patients treated with PCI.
- Monitoring hemoglobin may aid in risk stratification for cardiac events.
Background:
This study aims to investigate the association between hemoglobin and major adverse cardiac events (MACE) in patients with stable coronary artery disease (CAD) who were treated with percutaneous coronary intervention (PCI).
Methods:
This was a secondary analysis based on a retrospective cohort study involving 204 patients with stable CAD. Patients were divided into four groups according to hemoglobin levels (Q1: 6.90-12.30 g/dL; Q2: 12.40-13.80 g/dL; Q3: 13.90-14.90 g/dL; Q4: 15.00-19.00 g/dL). Lasso regression analysis was performed to select characteristic variables and reduce dimensions. Odds ratio (OR) and 95% confidence interval (CI) were used for comparing data among groups.
Results:
After an average follow-up of 783 days, 28/204 (17.72%) patients with CAD developed MACE. Univariate analysis data showed that hemoglobin level was negatively associated with the incidence of MACE in patients with CAD treated with PCI (Q2 vs Q1: OR=0.19, P=0.005; Q3 vs Q1: OR=0.25, P=0.013; Q4 vs Q1: OR=0.13, P=0.002). The negative correlation between hemoglobin and MACE still existed after adjusting selected variables obtained from multivariate regression analysis (Q2 vs Q1: OR= 0.18, P=0.007; Q3 vs Q1: OR=0.29, P=0.038; Q4 vs Q1: OR=0.19, P=0.016). Curve fitting illustrated that hemoglobin level presented a non-linear and negative association with MACE in patients with CAD treated with PCI.
Conclusions:
Hemoglobin level can be utilized as a prognostic indicator of MACE in patients with CAD after PCI.
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