Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

1.4K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
1.4K
Hypersensitivities01:30

Hypersensitivities

2.5K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
2.5K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.1K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.1K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.5K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.5K
Analgesia and Pain Management01:25

Analgesia and Pain Management

986
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
986
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

6.6K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights into the July 2026 Issue of the JOE.

Journal of endodontics·2026
Same author

Insights into the June 2026 Issue of the JOE.

Journal of endodontics·2026
Same author

Insights Into the May 2026 Issue of the JOE.

Journal of endodontics·2026
Same author

Insights into the April 2026 Issue of the JOE.

Journal of endodontics·2026
Same author

Insights into the March 2026 Issue of the JOE.

Journal of endodontics·2026
Same author

Insights Into the February 2026 Issue of the JOE.

Journal of endodontics·2026

Related Experiment Video

Updated: Oct 27, 2025

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

11.5K

Current Concepts of Dentinal Hypersensitivity.

Anita Aminoshariae1, James C Kulild2

  • 1Department of Endodontics, Case School of Dental Medicine, Cleveland State University, Cleveland, Ohio.

Journal of Endodontics
|July 24, 2021
PubMed
Summary
This summary is machine-generated.

Understanding dentinal sensitivity mechanisms is key for better dental pain treatments. This review explores five proposed theories, including hydrodynamic theory and neuroplasticity, to improve diagnostics and therapies.

Keywords:
Dentindentin hypersensitivitydentinal hypersensitivityhydrodynamic theoryodontoblasts

More Related Videos

Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites
07:04

Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites

Published on: November 9, 2014

13.8K
Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

1.4K

Related Experiment Videos

Last Updated: Oct 27, 2025

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

11.5K
Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites
07:04

Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites

Published on: November 9, 2014

13.8K
Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

1.4K

Area of Science:

  • Dentistry
  • Neuroscience
  • Pain Research

Background:

  • Limited research exists on dental pain mechanisms compared to prevalence.
  • Understanding these mechanisms is crucial for developing improved diagnostic tests and therapeutic interventions for dental pain.

Purpose of the Study:

  • To comprehensively review the existing literature on the mechanisms underlying dentinal sensitivity.

Main Methods:

  • A narrative review was conducted.
  • Literature search performed using PubMed and Ovid databases.
  • Articles focused on dentinal pain and pulpal sensitivity were included.

Main Results:

  • Five proposed mechanisms for dentinal sensitivity were identified:
  • 1. Classic hydrodynamic theory
  • 2. Direct innervation of dentinal tubules
  • 3. Neuroplasticity and sensitization of nociceptors
  • 4. Odontoblasts as sensory receptors
  • 5. Algoneurons

Conclusions:

  • The identified mechanisms are not mutually exclusive and may act in concert.
  • Pulpal inflammation can alter the contribution of these mechanisms, potentially leading to neuronal sprouting and peripheral sensitization.
  • Knowledge of these mechanisms can guide the development of targeted therapeutic drugs for effective pulpal pain management.