Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.3K
Epigenetic Regulation01:46

Epigenetic Regulation

31.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytoplasmic competition between separate parental pronuclei in zygotes.

Nature·2026
Same author

A hierarchical Rorc(γt) cis-regulatory cascade orchestrates differentiation of RORγt⁺ innate immune cells.

Immunity·2026
Same author

Reconstructing epigenomic dynamics through a single-cell multi-epigenome data integration framework.

Nature communications·2025
Same author

p53-mediated regulation of epiblast cell numbers predicts reactivation during mouse embryonic diapause.

Cell reports·2025
Same author

Cyclin-dependent kinase inhibitor 1A mediates mouse line- and fate-dependent cellular responses in Cx3cr1-Cre genetic tools.

Cell reports·2025
Same author

Transcriptional dynamics uncover the role of BNIP3 in mitophagy during muscle remodeling in <i>Drosophila</i>.

eLife·2025

Related Experiment Video

Updated: Oct 27, 2025

Reusable Single Cell for Iterative Epigenomic Analyses
10:28

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

1.5K

Recent advances in single-cell epigenomics.

Akihito Harada1, Hiroshi Kimura2, Yasuyuki Ohkawa1

  • 1Division of Transcriptomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-0054, Japan.

Current Opinion in Structural Biology
|July 24, 2021
PubMed
Summary
This summary is machine-generated.

Single-cell epigenome analysis advances genomics by revealing gene expression regulation. New in situ and multiomics methods profile chromatin and transcriptomes, identifying cell types and dynamic gene changes.

More Related Videos

DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments
09:14

DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments

Published on: January 27, 2016

19.7K
Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease
09:20

Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease

Published on: February 1, 2022

2.8K

Related Experiment Videos

Last Updated: Oct 27, 2025

Reusable Single Cell for Iterative Epigenomic Analyses
10:28

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

1.5K
DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments
09:14

DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments

Published on: January 27, 2016

19.7K
Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease
09:20

Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease

Published on: February 1, 2022

2.8K

Area of Science:

  • Genomics
  • Molecular Biology
  • Epigenetics

Background:

  • Single-cell epigenome analysis is crucial for understanding gene expression regulation.
  • Conventional methods like chromatin immunoprecipitation have limitations for single-cell studies.
  • Emerging technologies offer new ways to study the epigenome at the single-cell level.

Purpose of the Study:

  • To review novel approaches for single-cell epigenome analysis.
  • To highlight advancements in profiling gene expression regulation at single-cell resolution.
  • To discuss the potential of these technologies in cell biology research.

Main Methods:

  • In situ reactions using cells or nuclei with transposase tagging.
  • Development of single-cell multiomics techniques.
  • Simultaneous profiling of transcriptome and open chromatin or histone modifications.

Main Results:

  • New methods enable single-cell epigenome analysis without traditional immunoprecipitation.
  • Single-cell multiomics allows simultaneous transcriptome and epigenome profiling.
  • These techniques show potential for cell type identification and dynamic gene regulation studies.

Conclusions:

  • Novel single-cell epigenome analysis techniques are emerging.
  • These methods offer powerful tools for dissecting gene regulation.
  • Further development is needed for widespread application in genomics research.