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Updated: Oct 27, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Discovery of tert-amine-based RORγt agonists

Ruomeng Qiu1, Mingcheng Yu1, Juwen Gong1

  • 1Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.

European Journal of Medicinal Chemistry
|July 24, 2021
PubMed
Summary

New RORγt agonists were developed for cancer immunotherapy. These novel compounds show enhanced RORγt agonism, offering potential for small molecule therapeutics targeting Th17 cell responses.

Keywords:
Cancer immunotherapyRORγt agonistsSmall molecule drugsTertiary aminesTh17 cell differentiation

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