Related Experiment Video
Updated: Oct 27, 2025

In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
Published on: November 28, 2017
Sense of purpose in life predicts greater willingness for COVID-19 vaccination
Patrick L Hill1, Anthony L Burrow2, Victor J Strecher3
1Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Rationale:
Despite the clear public health significance of herd immunity to COVID-19, a host of individual differences influence willingness to get vaccinated. One factor likely to motivate individuals is the extent they have a sense of purpose in life, based on the health correlates of purpose and purposeful individuals' desire to return to their pre-pandemic environments.
Objective:
The current study examined sense of purpose as a predictor of COVID-19 vaccination willingness in the United States immediately following the initial approval of a COVID-19 vaccine in the United States in 2020.
Methods:
A nationwide sample of U. S. adults (N = 2009) completed a poll including information on their sense of purpose in life, demographic factors, and depressive symptoms, immediately following the initial approval of a COVID-19 vaccine in the United States in 2020. In addition, they reported on how willing they would be to get the vaccine, assuming that the costs would be covered, as well as their motivations to get the vaccine.
Results:
Multiple regression analyses found that sense of purpose predicted greater willingness to get vaccinated, even when accounting for demographic factors, political affiliation, and psychological wellbeing. Adults higher on sense of purpose reported greater importance of getting the vaccine for personal health, the health of others, and to return to regular activities. Exploratory analyses also suggest that purpose may provide a stronger impetus to vaccinate among those in age groups associated with lower risk for severe COVID-19 complications.
Conclusions:
Although cross-sectional in nature, the current findings suggest sense of purpose in life may be an important factor in encouraging vaccination. Implications are discussed regarding how purposeful messaging may yield greater vaccination rates among individuals who otherwise may be less motivated due to health concerns.
Related Concept Videos
Vaccinations
Motivational Bias
Self-Efficacy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Stress Prevention and Stress Management Techniques VI
Motivation and Self-Determination
Motivation, the driving force behind behavior, plays a pivotal role at every stage of the change process. The research...
Importance of Need for Affiliation

