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Updated: Oct 27, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Malignant transformation in a cohort of patients with oral epithelial dysplasia
P M Hankinson1, R I Mohammed-Ali2, A T Smith2
1Unit of Oral and Maxillofacial Pathology, The School of Clinical Dentistry, Claremont Crescent, Sheffield S10 2TA, UK.
Abstract:
Oral epithelial dysplasia (OED) is often diagnosed in oral potentially malignant disorders (OPMD) and carries an increased risk of malignant transformation. Currently, the reported risk of malignant transformation for OED varies. Here we present the risk in a cohort of 150 patients with OED at a specialist centre. In this cohort 2.6%, 4.1%, and 29.2% cases of mild, moderate, and severe OED, respectively, progressed to oral squamous cell carcinoma at the dysplastic site, while a small number developed a malignant lesion elsewhere. Moreover, 17 patients experienced an increase in grade of dysplasia and two showed histological resolution of their lesions.
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