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Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

88
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
88
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

59
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
59
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

60
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
60
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

100
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
100
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

96
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
96
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

125
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
125

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Related Experiment Video

Updated: Oct 27, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Invasive aspergillosis and endocarditis.

K Chevalier1, F Barde1, S Benhamida1

  • 1Department of Intensive Care Unit, Groupe Hospitalier Nord Essonne, Site Longjumeau, 159, rue du Président François Mitterrand, 91160 Longjumeau, France.

La Revue De Medecine Interne
|July 25, 2021
PubMed
Summary
This summary is machine-generated.

Aspergillus endocarditis (AE) is a rare but life-threatening fungal infection. Early recognition of predictive factors and clinical signs is crucial for timely diagnosis and improved survival rates in patients with invasive aspergillosis.

Keywords:
Abcès fungiquesAspergillus fumigatusEndocarditeEndocarditisFungal abscessesImmunocompromised patientPatient immunodépriméSolid organ transplantTransplantation d’organe

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Area of Science:

  • Infectious Diseases
  • Mycology
  • Cardiology

Background:

  • Invasive aspergillosis, caused by Aspergillus fumigatus, can lead to severe systemic infections with significant pulmonary and extra-pulmonary damage.
  • Aspergillus endocarditis (AE) is a rare but highly lethal manifestation of invasive aspergillosis.

Observation:

  • This report details five cases of endocarditis attributed to invasive aspergillosis in diverse patient populations, including those with immunosuppression (kidney graft, chemotherapy, corticosteroids, HIV, autoimmune neutropenia).
  • Aspergillus species constitute a significant proportion of fungal endocarditis cases (25-30%) and a small percentage of all infectious endocarditis cases (0.25-8.5%).

Findings:

  • Aspergillus endocarditis is characterized by a high mortality rate (42-68%) and diagnostic challenges, including frequently negative blood cultures and the absence of fever.
  • Key predictors for AE include immunosuppression, hematological malignancies, recent cardiothoracic surgery, negative blood cultures, and embolic events.
  • Distinct clinical features suggestive of AE over non-fungal endocarditis include lack of fever, specific vegetation locations (mitral valve, non-valve, aortotomy sites), and the presence of aortic abscess or pseudo-aneurysm.

Implications:

  • Early suspicion of aspergillosis in endocarditis cases, guided by specific clinical indicators, is vital for prompt diagnosis.
  • Diagnostic methods for invasive aspergillosis involve chest CT scans, microscopy, culture, serological, and molecular tests.
  • Effective treatment necessitates triazole antifungal drugs, often combined with surgical intervention for debridement.