Multiscale models quantifying yeast physiology: towards a whole-cell model

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Updated: Oct 27, 2025

ODELAY: A Large-scale Method for Multi-parameter Quantification of Yeast Growth

ODELAY: A Large-scale Method for Multi-parameter Quantification of Yeast Growth

Published on: July 3, 2017

Hongzhong Lu¹, Eduard J Kerkhoven¹, Jens Nielsen²

¹Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE412 96 Gothenburg, Sweden.

Trends in Biotechnology

|July 25, 2021

Abstract:

The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important eukaryal model organism for studying cellular physiology related to human health and disease. Yeast was also the first eukaryal organism for which a genome-scale metabolic model (GEM) was developed. In recent years there has been interest in expanding the modeling framework for yeast by incorporating enzymatic parameters and other heterogeneous cellular networks to obtain a more comprehensive description of cellular physiology. We review the latest developments in multiscale models of yeast, and illustrate how a new generation of multiscale models could significantly enhance the predictive performance and expand the applications of classical GEMs in cell factory design and basic studies of yeast physiology.

Keywords:

S. cerevisiae multiscale model whole-cell model yeast species

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